Set in the near-future, mind-control technology has taken society by storm and a multiplayer on-line game called "Slayers" allows gamers to control human death row prisoners in mass-scale deathmatches, if an inmate lives through 30 matches then he wins his freedom. Simon (Lerman) controls Kable (Butler) the on-line champion of the game having won 27 matches and lived through them all, with his every move tracked by millions, his ultimate challenge becomes regaining his identity and independence by defeating the game's mastermind (Hall) through launching an attack on the system that has imprisoned him


* Gerard Butler as Kable, the highest-ranked warrior in the game "Slayers"
* Logan Lerman as Simon, who controls Kable
* Milo Ventimiglia as Rick Rape, described as "Moonraker, silver grill, with a latex outfit making him look like a bumblebee."
* Aaron Yoo as Humanez Dude
* Ludacris as Humanez Brother
* Terry Crews as Hackman
* Alison Lohman as Trace
* Kyra Sedgwick as Gina Parker Smith
* Michael C. Hall as Ken Castle
* John Leguizamo as Freek
* Johnny Whitworth as Scotch
* Zoe Bell as Sandra
* Amber Valletta as Angie
* Efren Ramirez as DJ Twist